In a sauce pan over medium heat, add ingredients for the sauce. Stir to combine and cook for 5 minutes. Reduce to low and let simmer.
In a separate bowl, add melted butter, garlic powder, parsley and onion powder.
Lay split rolls (inside up) out on a baking rack over a parchment paper covered baking sheet. Brush each with the seasoned melted butter mix. Place in oven for 8 minutes.
Removed tossed rolls from oven and spoon red sauce onto each. Add a portion of mozzarella cheese, then 4-5 slices of pepperoni. Add another small portion of mozzarella cheese, sprinkle with parmesan cheese and then Italian seasoning. Return baking sheet to the oven for 10-12 minutes (until tops are golden brown).